H340 · Hazard statementMay cause genetic defects (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard)

Hazard statementHealth

H340 is the GHS hazard statement “May cause genetic defects (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard)”. It is used for Germ cell mutagenicity (chapter 3.5), Category 1, 1A, 1B. The English wording is the same as UN GHS Rev.11 in US OSHA, EU CLP and Canada. The Canadian French and Mexican Spanish wording is in the table below. The UN GHS Rev.11 label matrix lists 5 precautionary statements for it (UN only).

Maintained by Valenc. Data checked 2026-10-20.

Heading text: UN GHS Rev.11 Annex 3. Wording can differ by jurisdiction; see the table below.

Wording by jurisdiction

UN GHS Rev.11

Same as UN

GHS Rev.11 (2025), Annex 3

May cause genetic defects (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard)

UN GHS Rev.11, Annex 3, Table A3.1.2, PDF p. 304

US OSHA HCS

Same as UN

HCS 2024 · primarily GHS Rev.7, some Rev.8

May cause genetic defects <…>

29 CFR 1910.1200 App. C, matched by wording

EU CLP

Same as UN

EU_CLP_2025 · consolidated 1 Jul 2026

May cause genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

EU CLP (Reg. (EC) No 1272/2008), Annex III, Part 1

Canada (EN)

Same as UN

WHMIS_2022 · GHS Rev.7 (Rev.8 for chemicals under pressure)

May cause genetic defects (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard)

GHS Rev.7 Annex 3 Table A3.1

Canada (FR)

Adopted

WHMIS_2022 · SGH Rév.7, texte officiel

Peut induire des anomalies génétiques (indiquer la voie d'exposition s'il est formellement prouvé qu'aucune autre voie d'exposition ne conduit au même danger)

GHS Rev.7 Annex 3 Table A3.1

Mexico (ES)

Adopted

NOM-018-STPS-2015 · GHS 5th revised edition

Puede provocar defectos genéticos (indíquese la vía de exposición si se ha demostrado concluyentemente que ninguna otra vía es peligrosa)

Mutagenicidad en células germinales · 1A, 1B

NOM-018-STPS-2015, DOF 9 October 2015, Apéndice C, Tabla C.2, PDF p. 32

Hazard classes and categories

Germ cell mutagenicity (chapter 3.5) · Category 1, 1A, 1B

UN GHS Rev.11 Annex 3, sections 1 and 2

FRMutagénicité pour les cellules germinales (chapitre 3.5) · catégorie 1A, 1B

ESMutagenicidad en células germinales · 1A, 1B (NOM-018-STPS-2015)

Pictogram: Health hazard (GHS08)

UN GHS Rev.11 Annex 3, section 3. Pictogram rules can differ by jurisdiction; see the GHS pictogram guide.

P statements in the UN GHS Rev.11 label matrix only

UN GHS Rev.11 only. EU CLP, US OSHA, Canada (GHS Rev.7) and Mexico assign different P statements; check the regulation for your market.

Germ cell mutagenicity (chapter 3.5), categories 1, 1A, 1B, 2 (PDF p. 395)
P203 P280 P318 P405 P501

UN GHS Rev.11 Annex 3, section 3. Each table covers the categories named; a P statement may apply to only some of them. Many apply only under conditions; check the conditions for use before putting them on a label.

Related codes

H341

Change in UN GHS Rev.11

No change to the wording or the hazard classes in Annex 3 compared with Rev.10.

Sources

Each cell in the table names the official table and page for H340. Full citations, links and revision notes for UN GHS Rev.11, US OSHA, EU CLP, Canada and Mexico: Sources and revision notes.

These are regulatory phrases for labels and safety data sheets. Check them against the official source for your jurisdiction before use.