P381 · Precautionary statementIn case of leakage, eliminate all ignition sources.

Precautionary · ResponsePhysical

P381 is the GHS precautionary statement “In case of leakage, eliminate all ignition sources”. UN GHS Annex 3 assigns it to Flammable gases (chapter 2.2), Category Flammable gas, Pyrophoric gas, 1A, Chemically unstable gas A, Chemically unstable gas B, 1B, 2 and Chemicals under pressure (chapter 2.3), Category 1, 2. The English wording is the same as UN GHS Rev.11 in US OSHA, EU CLP and Canada. Canada’s official French text is “En cas de fuite, éliminer toutes les sources d'ignition” and Mexico’s Spanish text is “En caso de fuga, eliminar todas las fuentes de ignición”. In the UN GHS Rev.11 label matrix it is used with 7 hazard statements (UN only).

Maintained by Valenc. Data checked 2026-10-20.

Heading text: UN GHS Rev.11 Annex 3. Wording can differ by jurisdiction; see the table below.

Wording by jurisdiction

UN GHS Rev.11

Same as UN

GHS Rev.11 (2025), Annex 3

In case of leakage, eliminate all ignition sources.

UN GHS Rev.11, Annex 3, Table A3.2.3, PDF p. 328

US OSHA HCS

Same as UN

HCS 2024 · primarily GHS Rev.7, some Rev.8

In case of leakage, eliminate all ignition sources.

29 CFR 1910.1200 App. C, matched by wording

EU CLP

Same as UN

EU_CLP_2025 · consolidated 1 Jul 2026

In case of leakage, eliminate all ignition sources.

EU CLP, Annex IV, Part 2

Canada (EN)

Same as UN

WHMIS_2022 · GHS Rev.7 (Rev.8 for chemicals under pressure)

In case of leakage, eliminate all ignition sources.

GHS Rev.7 Annex 3 Table A3.2

Canada (FR)

Adopted

WHMIS_2022 · SGH Rév.7, texte officiel

En cas de fuite, éliminer toutes les sources d'ignition.

GHS Rev.7 Annex 3 Table A3.2

Mexico (ES)

Adopted

NOM-018-STPS-2015 · GHS 5th revised edition

En caso de fuga, eliminar todas las fuentes de ignición

NOM-018-STPS-2015, DOF 9 October 2015, Apéndice D, Tabla D.1, PDF p. 37

Hazard classes and categories

Flammable gases (chapter 2.2) · Category Flammable gas, Pyrophoric gas, 1A, Chemically unstable gas A, Chemically unstable gas B, 1B, 2
Chemicals under pressure (chapter 2.3) · Category 1, 2

UN GHS Rev.11 Annex 3, sections 1 and 2

H statements it is used with in the UN GHS Rev.11 label matrix only

UN GHS Rev.11 only. EU CLP, US OSHA, Canada (GHS Rev.7) and Mexico assign their own P statements; check the regulation for your market.

H220 H221 H230 H231 H232 H282 H283

UN GHS Rev.11 Annex 3, section 3. Listed for at least one category that uses each H statement.

Change in UN GHS Rev.11

No change to the wording or the hazard classes in Annex 3 compared with Rev.10.

Sources

Each cell in the table names the official table and page for P381. Full citations, links and revision notes for UN GHS Rev.11, US OSHA, EU CLP, Canada and Mexico: Sources and revision notes.

These are regulatory phrases for labels and safety data sheets. Check them against the official source for your jurisdiction before use.