P321 · Precautionary statementSpecific treatment (see information on this label and safety data sheet).

Precautionary · ResponseHealthChanged in Rev.11Differs: US, EU, Canada

P321 is the GHS precautionary statement “Specific treatment (see information on this label and safety data sheet)”. UN GHS Annex 3 assigns it to 7 hazard classes. The wording differs in US OSHA, EU CLP and Canada. Canada’s official French text is “Traitement spécifique (voir … sur cette étiquette)” and Mexico’s Spanish text is “Tratamiento específico (véase... en esta etiqueta)”. In the UN GHS Rev.11 label matrix it is used with 7 hazard statements (UN only). Changed in UN GHS Rev.11: wording changed, hazard classes/categories changed.

Maintained by Valenc. Data checked 2026-10-20.

Heading text: UN GHS Rev.11 Annex 3. Wording can differ by jurisdiction; see the table below.

Wording by jurisdiction

UN GHS Rev.11

Same as UN

GHS Rev.11 (2025), Annex 3

Specific treatment (see information on this label and safety data sheet).

UN GHS Rev.11, Annex 3, Table A3.2.3, PDF p. 324

US OSHA HCS

Differs

HCS 2024 · primarily GHS Rev.7, some Rev.8

Specific treatment (see … on this label)

29 CFR 1910.1200 App. C, matched by wording

EU CLP

Differs

EU_CLP_2025 · consolidated 1 Jul 2026

Specific treatment (see … on this label).

EU CLP, Annex IV, Part 2

Canada (EN)

Differs

WHMIS_2022 · GHS Rev.7 (Rev.8 for chemicals under pressure)

Specific treatment (see ... on this label).

GHS Rev.7 Annex 3 Table A3.2

Canada (FR)

Adopted

WHMIS_2022 · SGH Rév.7, texte officiel

Traitement spécifique (voir … sur cette étiquette).

GHS Rev.7 Annex 3 Table A3.2

Mexico (ES)

Adopted

NOM-018-STPS-2015 · GHS 5th revised edition

Tratamiento específico (véase... en esta etiqueta)

NOM-018-STPS-2015, DOF 9 October 2015, Apéndice D, Tabla D.1, PDF p. 36

Hazard classes and categories

Acute toxicity, oral (chapter 3.1) · Category 4
Acute toxicity, dermal (chapter 3.1) · Category 4
Acute toxicity, inhalation (chapter 3.1) · Category 4
Skin corrosion (chapter 3.2) · Category 1, 1A, 1B, 1C
Skin irritation (chapter 3.2) · Category 2
Skin sensitization (chapter 3.4) · Category 1, 1A, 1B
Specific target organ toxicity, single exposure (chapter 3.8) · Category 1

UN GHS Rev.11 Annex 3, sections 1 and 2

H statements it is used with in the UN GHS Rev.11 label matrix only

UN GHS Rev.11 only. EU CLP, US OSHA, Canada (GHS Rev.7) and Mexico assign their own P statements; check the regulation for your market.

H302 H312 H314 H315 H317 H332 H370

UN GHS Rev.11 Annex 3, section 3. Listed for at least one category that uses each H statement.

Conditions for use

- if immediate measures that can be easily applied, such as the administration of antidote or other specific treatment are required. These measures must be specified on the label and safety data sheet, recognizing additional detailed instructions, including any training requirements, should be provided on the safety data sheet, if appropriate. - may be omitted if P320 is given on the label.

Quoted as published in UN GHS Rev.11 Annex 3, section 2. List markers are shown as bullets.

Change in UN GHS Rev.11

Changed from Rev.10: wording changed, hazard classes/categories changed.

Rev.10 text: Specific treatment (see ... on this label).

Rev.10 only:

Acute toxicity, oral (chapter 3.1): 1, 2, 3
Acute toxicity, dermal (chapter 3.1): 1, 2, 3, 4
Acute toxicity, inhalation (chapter 3.1): 3

Rev.11:

Acute toxicity, oral (chapter 3.1): 4
Acute toxicity, dermal (chapter 3.1): 4
Acute toxicity, inhalation (chapter 3.1): 4

Notes

EU CLP wording differs from UN GHS Rev.11.

Sources

Each cell in the table names the official table and page for P321. Full citations, links and revision notes for UN GHS Rev.11, US OSHA, EU CLP, Canada and Mexico: Sources and revision notes.

These are regulatory phrases for labels and safety data sheets. Check them against the official source for your jurisdiction before use.